| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Yacht Club Estates | city | South Carolina | United States | 32.41 | -80.67 | 9 | |
| Yacht Cove | city | South Carolina | United States | 34.07 | -81.23 | 400 | |
| Yale (historical) | city | South Carolina | United States | 33.28 | -81.33 | 219 | |
| Yarborough Crossroads | city | South Carolina | United States | 34.24 | -80.02 | 170 | |
| Yauhannah | city | South Carolina | United States | 33.63 | -79.19 | 26 | |
| Yaupon Circle | city | South Carolina | United States | 33.68 | -78.89 | 0 | |
| Yellow House (historical) | city | South Carolina | United States | 32.89 | -79.92 | 9 | |
| Yellow House Landing | city | South Carolina | United States | 32.91 | -79.92 | 22 | |
| Yemassee | city | South Carolina | United States | 32.69 | -80.85 | 19 | |
| Yenome | city | South Carolina | United States | 33.18 | -81.35 | 200 | |
| Yonges Island | city | South Carolina | United States | 32.69 | -80.23 | 3 | |
| York | city | South Carolina | United States | 34.99 | -81.24 | 830 | |
| York Hills | city | South Carolina | United States | 35.04 | -81.65 | 830 | |
| York Terrace | city | South Carolina | United States | 34.72 | -81.21 | 830 | |
| Yorkdale | city | South Carolina | United States | 34.91 | -80.93 | 830 | |
| Yorkshire | city | South Carolina | United States | 33.98 | -80.94 | 278 | |
| Yorkwood | city | South Carolina | United States | 34.80 | -82.55 | 961 | |
| Youngs | city | South Carolina | United States | 34.67 | -82.08 | 830 |